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M9480512.TXT
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1994-08-20
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Document 0512
DOCN M9480512
TI Improvement in CD4 lymphocyte count in HIV-Reiter's syndrome after
treatment with sulfasalazine.
DT 9410
AU Disla E; Rhim HR; Reddy A; Taranta A; Department of Medicine, Cabrini
Medical Center, New York, NY; 10003.
SO J Rheumatol. 1994 Apr;21(4):662-4. Unique Identifier : AIDSLINE
MED/94309030
AB OBJECTIVE. To describe an observed improvement in CD4 lymphocytes in
patients with Reiter's syndrome (RS) and human immunodeficiency virus
(HIV) infection, after treatment with sulfasalazine (SFSZ). METHODS .
Care series. We analyzed CD4 lymphocyte counts in 4 consecutive patients
with RS and HIV disease before and after treatment with SFSZ. RESULTS.
CD4+ lymphocyte counts increased from a mean of 315 +/- 179 before
treatment to 542 +/- 231 x 10(6)/l on followup (p < 0.03), in the
absence of antiretroviral therapy. The significance of these
observations is discussed. CONCLUSION. Treatment of RS with SFSZ in HIV
disease appears to be associated with an improvement in CD4 count.
DE Adult Case Report CD4-CD8 Ratio/DRUG EFFECTS Human HIV
Infections/BLOOD/COMPLICATIONS/*DRUG THERAPY Leukocyte Count Male
Middle Age Reiter's Disease/BLOOD/COMPLICATIONS/*DRUG THERAPY
Salicylazosulfapyridine/*THERAPEUTIC USE Time Factors T4
Lymphocytes/*DRUG EFFECTS JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).